American University of Beirut Medical Center, Beirut, Lebanon 11-0236LB
Dr. Ahmad Husari's Pulmonary Research Publications
Basic Science
Dr. Ahmad Husari's clinical research focuses on basic science related to the parthenogenesis of lung injury and other organ injuries caused by inhaling harmful chemicals, primarily hyperoxia and tobacco smoke. His studies also extend to pulmonary disorders associated with combustible tobacco and electronic cigarette use. Dr. Husari has developed a state-of-the-art inhalational animal model that documents the detrimental effects of these substances, contributing valuable insights to the understanding of both pulmonary and sleep disorders.
Clinical science /Research
Clinical Research
My clinical research focuses on identifying elements or interventions that may impact outcomes or predict complications in patients undergoing medical or surgical procedures. This includes investigating pulmonary disorders and their effects on recovery.
· The six-minute walk test and SF-36 as preoperative predictors of operative morbidity and mortality in patients undergoing high-risk surgery.
The study concluded that the 6-minute walk test (6-MWT) and the Short Form-36 Health Survey (SF-36) are valuable tools in predicting postoperative cardiopulmonary complications in patients, particularly those facing high-risk surgery, which can also include assessments related to sleep disorders.
· The untold story of Dabigatran etexilate: alveolar hemorrhage in an elderly patient with interstitial pulmonary fibrosis.
· Rivaroxaban for thromboprophylaxis in acutely ill medical patients.
With the introduction of direct thrombin inhibitors and oral direct factor Xa inhibitors, we promptly reported our observations on potential complications. Our findings were published in the New England Journal of Internal Medicine and the Journal of Thrombosis and Thrombolysis.
Recent Publications
The substitution of fifty percent of combustible tobacco smoke exposure with either electronic cigarettes or heated tobacco products did not attenuate acute lung injury in an animal model, highlighting important findings in clinical research related to pulmonary disorders.
Husari A, El-Harakeh M, Shihadeh A, Daou MAZ, Bitar H, Karaoghlanian N, Zaatari G, El-Sabban M. Nicotine Tob Res. 2023 Jun 9;25(7):1361-1368. doi: 10.1093/ntr/ntad045.
Additionally, life-threatening complications have been observed post-liposuction, which can also be relevant in studies focusing on clinical research and its implications for patient safety.
Ezzeddine H, Husari A, Nassar H, Kanso M, Nounou GE, Khalife M, Faraj W. Aesthetic Plast Surg. 2018 Apr;42(2):384-387. doi: 10.1007/s00266-017-1058-x. Epub 2018 Jan 31. PMID: 29387943
In another study, pomegranate juice was found to prevent the formation of lung nodules secondary to chronic cigarette smoke exposure in an animal model, further emphasizing the connection between dietary factors and pulmonary disorders.
Husari A, Hashem Y, Zaatari G, El Sabban M. Oxid Med Cell Longev. 2017;2017:6063201. doi: 10.1155/2017/6063201. Epub 2017 Nov 30
Acute exposure to cigarette smoking followed by myocardial infarction also aggravated renal damage in an in vivo mouse model, demonstrating the multifaceted impact of smoking on health, which is crucial for clinical research.
Kobeissy F, Shaito A, Kaplan A, Baki L, Hayek H, Dagher-Hamalian C, Nehme A, Ghali R, Abidi E, Husari A, Zeidan A, Zouein FA, Zibara K. Oxid Med Cell Longev. 2017;2017:5135241. doi: 10.1155/2017/5135241. Epub 2017 Oct 22
Furthermore, research into the disruption of adherens junctions and alterations in YAP-related proliferation behavior provides insight into the underlying cell transformation processes involved in alcohol-induced oral carcinogenesis, which is relevant for understanding various health conditions including those impacting sleep disorders.
Husari A, Hülter-Hassler D, Steinberg T, Schulz SD, Tomakidi P. Biochim Biophys Acta Mol Cell Res. 2018 Jan;1865(1):209-219. doi: 10.1016/j.bbamcr.2017.10.015. Epub 2017 Nov 2.
Lastly, electronic cigarette smoke has been shown to impair normal mesenchymal stem cell differentiation, which is a significant concern in the context of pulmonary disorders and overall health.
Shaito A, Saliba J, Husari A, El-Harakeh M, Chhouri H, Hashem Y, Shihadeh A, El-Sabban M. Sci Rep. 2017 Oct 27;7(1):14281. doi: 10.1038/s41598-017-14634-z. PMID: 29079789
Clinical research plays a crucial role in understanding various health issues, including pulmonary disorders and sleep disorders. By studying these conditions, researchers can develop better treatment options and improve patient outcomes.